Fiber substrate-based fluidic analytical devices and methods of making and using the same
AssigneeOregon State University
InventorsVincent Remcho, Saichon Sumantakul
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Abstract
Embodiments of fiber substrate-based fluidic device and methods of manufacturing the same are described herein. In one example, a method of manufacturing a fiber substrate-based fluidic device comprises bonding a hydrophobic film that is substantially transparent to a laser beam (e.g., a film that transmits at least 80% of the incident radiant power of the laser beam) to a hydrophilic substrate and ablating the hydrophilic substrate with the laser beam without ablating the hydrophobic film to form one or more fluidly sealed channels in the hydrophilic substrate.
Claims18
A method, comprising:
- bonding a hydrophobic film to a hydrophilic substrate;
- directing a laser beam through the hydrophobic film to the hydrophilic substrate, wherein the hydrophobic film transmits at least 80% of the incident radiant power of the laser beam;
- and
- ablating the hydrophilic substrate with the laser beam without ablating the hydrophobic film.
A method for manufacturing a microfluidic device, comprising:
- bonding a first hydrophobic film to a first side of a hydrophilic substrate and bonding a second hydrophobic film to an opposite second side of the hydrophilic substrate;
- and
- directing a laser beam through at least one of the hydrophobic films without ablating the hydrophobic film and ablating the hydrophilic substrate with the laser beam, wherein the hydrophobic film transmits at least 80% of the incident radiant power of the laser beam.
A method for manufacturing a microfluidic device, comprising:
- stacking three hydrophobic films and two hydrophilic substrates in an alternating order to form a 5-layer stacked component;
- bonding the 5-layer stacked component;
- and
- ablating one of the hydrophilic substrates by directing a laser beam through one of the hydrophobic films from a first side of the 5-layer stacked component and ablating the other one of the hydrophilic substrates by directing the laser beam through one of the other hydrophobic films from an opposite second side of the 5-layer stacked component.
A microfluidic diagnostic device for detecting the presence and/or concentration of an analyte, the fiber substrate-based fluidic device comprising:
- a nitrocellulose substrate sandwiched between two bonded layers of a hydrophobic film, wherein the nitrocellulose substrate comprises a plurality of wells and/or fluidic channels formed in the nitrocellulose substrate such that boundaries of the wells and/or fluidic channels are defined by the nitrocellulose and at least one of the bonded layers of the hydrophobic film.
Dependencies are inferred from the claim text.