Targeted in Situ Therapeutic Delivery of Secreted Factors from Stem Cells for Treatment of Damaged Tissue
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government AS Represented By the Department of Veteran Affairs, The Board of Trustees of the University of Illinois
InventorsDavid Myung, Gabriella Fernandes-Cunha, Hyun Jong Lee, Ali Djalilian
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Abstract
Compositions and methods for repairing or regenerating damaged tissue are disclosed. In particular, the invention relates to methods of delivering secreted factors from stem cells to tissues in order to immobilize and concentrate such secreted factors at or under the surface of damaged tissue to promote tissue regeneration.
Claims62
A method of treating damaged tissue in a subject, the method comprising:
- a) collecting one or more secreted factors from a stem cell;
- b) mixing the one or more secreted factors from the stem cell with a solution comprising at least one biocompatible polymer or biopolymer to form a mixture;
- and
- c) applying the mixture to the damaged tissue, wherein the one or more secreted factors from the stem cell accelerate healing of the damaged tissue.
A method of treating damaged tissue in a subject, the method comprising:
- a) collecting secretome from conditioned media of a culture of stem cells;
- b) mixing the secretome with hyaluronic acid and chondroitin sulfate to form a mixture;
- and
- c) applying the mixture to the damaged tissue.
A composition comprising factors secreted from a stem cell encapsulated in a gel comprising hyaluronic acid (HA).
Dependencies are inferred from the claim text.