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US 2022/0088217 A1Published application
Compositions and methods for delivery of rna
AssigneeHDT Bio Corp.
InventorsAmit KHANDHAR, Steven REED, Malcolm DUTHIE, Jesse ERASMUS, Darrick CARTER, Bryan J. BERUBE
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Abstract
The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
Claims28
A nanoemulsion composition comprising a plurality of nanoemulsion particles, wherein the plurality of nanoemulsion particles comprise:
- a hydrophobic core comprising a mixture of a liquid oil and a solid inorganic nanoparticle;
- a cationic lipid;
- a hydrophilic surfactant;
- a hydrophobic surfactant;
- and
- a nucleic acid, wherein the nucleic acid modulates innate immune response and is complexed with the nanoemulsion particles.
3 more elements
Dependencies are inferred from the claim text.