Phlip®-mediated intracellular delivery of immuno-stimulatory compounds
AssigneesUniversity of Rhode Island Board of Trustees, Yale University
InventorsYana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman, Anna Moshnikova, John Deacon
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Abstract
The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.
Claims27
A composition comprising an immuno-stimulatory compound and a pHLIP® peptide.
A method of augmenting an anti-tumor immune response, comprising administering to a subject a composition comprising an immuno-stimulatory compound and a pHLIP® peptide.
Dependencies are inferred from the claim text.