Pharmaceutical preparation containing polyethylene gylcol loxenatide and preparation method thereof
AssigneeJiangsu Hansoh Pharmaceutical Group Co., Ltd.
InventorsLi Dong, Ge Wang, Di Hu, Yundong Sun, Hengli Yuan
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Abstract
Disclosed are a GLP-1-mimicking pharmaceutical composition for treating type 2 diabetes and a preparation method thereof, wherein the pharmaceutical composition contains polyethylene glycol loxenatide, a physiologically acceptable buffer with the pH of 3.0-7.0, and pharmaceutically acceptable excipients. The pharmaceutical composition has good drug stability.
Claims18
A pharmaceutical composition of polyethylene glycol loxenatide, the pharmaceutical composition comprising polyethylene glycol loxenatide as an active ingredient, a buffer and an isosmotic regulator, wherein the polyethylene glycol loxenatide has a structure of
A method for preparing a pharmaceutical composition of polyethylene glycol loxenatide comprising the steps of:
- 1) dissolving a buffer salt and an isosmotic regulator in water for injection;
- 2) adding activated carbon, and then filtering the mixture to remove the activated carbon to obtain an intermediate solution;
- and
- 3) dissolving polyethylene glycol loxenatide in the solution obtained in step 2) under stirring, filtering and dispensing the resulting composition.
Dependencies are inferred from the claim text.