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US 2022/0088189 A1Published application
Immune modulation
AssigneeSementis Limited
InventorPaul Michael HOWLEY
Life of this patent
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Abstract
The present invention relates to a poxvirus vector comprising a nucleic acid sequence encoding a fusion protein comprising: (i) a peanut allergen selected from list consisting of at least two peanut allergens from ara h 1, ara h 2, ara h 3, ara h 4, ara h 5, ara h 6, ara h 7, ara h 8, ara h 9, ara h 8, ara h 9, ara h 10 and ara h 11 or a derivative or part thereof having at least 70% sequence identity thereto, and (ii) a proteasome degradation tag to enhance intracellular degradation of the fusion protein.
Claims16
A poxvirus vector comprising a nucleic acid sequence encoding a fusion protein comprising:
- (i) at least two peanut allergens selected from the group consisting of ara h 1, ara h 2, ara h 3, ara h 4, ara 5, ara h 6, ara h 7, ara h 8, ara h 9, ara h 10 and ara h 11, and a derivative or part thereof having at least 70% sequence identity thereto, and
- (ii) a proteasome degradation tag to enhance intracellular degradation of the fusion protein.
Dependencies are inferred from the claim text.