Optimized vaccine compositions and methods for making the same
AssigneeCentivax, Inc.
InventorsJacob GLANVILLE, Sarah IVES, Michal IZHAKY, Sawsan YOUSSEF, Jean-Philippe BÜRCKERT
Life of this patent
Estimating the term…
Abstract
Described herein are compositions of and methods of making vaccines which can provide broad serological reactivity an inverse dose response, and a swarm effect.
Claims30
1-12. (canceled)
A vaccine composition comprising at least 4 influenza virus hemagglutinin antigen polypeptides, each polypeptide represented by an amino acid sequence that is at least 20% identical, but not more than 95% identical, to the other influenza virus hemagglutinin antigen polypeptides in the vaccine composition, wherein each polypeptide comprises an antigen that is at least 90% identical among the 4 influenza virus hemagglutinin antigen polypeptides.
A vaccine composition comprising at least 4 influenza virus neuraminidase antigen polypeptides, each polypeptide represented by an amino acid sequence that is at least 20% identical, but not more than 95% identical, to the other influenza virus neuraminidase antigen polypeptides in the vaccine composition, wherein each polypeptide comprises an antigen that is at least 90% identical among the 4 influenza virus neuraminidase antigen polypeptides.
15-25. (canceled)
30-45. (canceled)
(canceled)
(canceled)
50-98. (canceled)
100-106. (canceled)
108-115. (canceled)
A recombinant expression vector comprising a nucleic acid molecule encoding at least one antigen that is at least 80% identical to any one of SEQ ID NOs:1-267.
A virus like particle (VLP) comprising a vaccine composition, wherein the vaccine composition comprises at least one antigen that is at least 80% identical to any one of SEQ ID NOs:1-267.
A method for treating or reducing the likelihood of an infection in a subject, comprising administrating to the subject a vaccine composition, wherein the vaccine composition comprises at least one antigen that is at least 80% identical to any one of SEQ ID NOs:
- 1-267.
Dependencies are inferred from the claim text.