Vaccine composition for preventing tuberculosis, comprising glycosylated ag85a protein and method for preparing same

Abstract

The present invention relates to a vaccine composition for preventing tuberculosis comprising a glycosylated Ag85A protein, a vector for preparing the protein, a transformant using the vector, and a method for producing the glycosylated Ag85A protein by using the transformant. A vaccine composition comprising a glycosylated Ag85A protein of the present invention has the effect of inducing an increase in multifunctional T cells simultaneously secreting IFN-γ, TNF-α, and IL-2 which are important in regard to a protective effect against tuberculosis, and thus can be usefully used as a vaccine for preventing tuberculosis. Furthermore, the glycosylated Ag85A protein can be effectively expressed in plants and separated with high yield by means of a vector optimized for protein production, and thus can be mass produced at low cost.

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