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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsQiong J. Wang, Zhiya Yu, James C. Yang
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Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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An isolated or purified T cell receptor (TCR) having antigenic specificity for a mutated epitope, the amino acid sequence of the mutated epitope consisting of the amino acid sequence of VVVGADGVGK (SEQ ID NO:
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