Methods for detecting and modulating the embryonic-fetal transition in mammalian species
AssigneeAgeX Therapeutics, Inc.
InventorsMichael D. West, Dana Larocca
Life of this patent
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Abstract
Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
Claims21
-20. (canceled)
A method for treating diseases or disorders of the eye in a subject in need thereof, the method comprising contacting one or more cells of the eye of the subject in vivo with one or more induced tissue regeneration (iTR) factors that comprise one or more nucleic acids encoding OCT4, SOX2, KLF4, NANOG, ESRRB, NR5A2, CEBPA, MYC, TERT, LIN28A, LIN28B, or any combination thereof, wherein the one or more cells of said damaged tissue do not revert to pluripotent stem cells, and wherein contacting the cells with one or more iTR factors is for 4 or 7 days.
A method for treating diseases or disorders of the eye in a subject in need thereof, the method comprising contacting one or more cells of the eye of the subject with one or more induced tissue regeneration (iTR) factors that comprise one or more nucleic acids encoding OCT4, SOX2, KFL4, TERT, or a combination thereof, wherein the one or more cells of said damaged tissue do not revert to pluripotent stem cells, and wherein contacting the cells with one or more iTR factors is for 4 or 7 days.
Dependencies are inferred from the claim text.