Methods for detecting and modulating the embryonic-fetal transition in mammalian species
AssigneeAgeX Therapeutics, Inc.
InventorsMichael D. West, Dana Larocca
Life of this patent
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Abstract
Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
Claims18
-20. (canceled)
A method of regenerating tissue in a human subject, the method comprising contacting the one or more cells in vivo with one or more induced tissue regeneration (iTR) factors that comprise one or more nucleic acids encoding OCT4, SOX2, KLF4, and MYC, wherein the one or more cells of said tissue do not revert to pluripotent stem cells, wherein the one or more iTR factors are contained by a viral vector, and wherein contacting the cells with one or more iTR factors is for 4 or 7 days.
Dependencies are inferred from the claim text.