Specific peptide clathrin inhibitors
AssigneeOleg Arkadyevich KOTIN
InventorsOLEG Arkadyevich KOTIN, Arkadiy Mihaylovich KOTIN, Maksim Olegovich EMELYANOV
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Abstract
The method of synthetic peptides as specific clathrin inhibitors has been proposed. Also proposed is a method for the prevention or treatment of a disease or condition in an animal having administering an effective amount of peptides or a prodrug or a physiologically acceptable salt or solvate of the above peptides, or a pharmaceutical composition containing the above peptides as specific clathrin inhibitors. Peptides can be used in medicine, veterinary medicine and pharmacology to create new drugs that are specific clathrin inhibitors.
Claims2
A method of inhibiting clathrin comprising administering synthetic peptide of general formula (I) [SEQ ID NO:
- 1]
- XDL-XDL1-XDL2-L-Lys-L-Leu-XDL3-L-Thr-R2 (I)
- wherein:
- XDL—the absence of an amino acid or L-Tyr,
- XDL1—one of the amino acids:
- L-Leu, L-Ala or D-Ala,
- XDL2—one of the amino acids:
- L-His, D-His, L-Ala or D-Ala,
- XDL3—one of the amino acids:
- L-Gln, L-Ala or D-Ala;
- R2—OMe or NH2,
- or peptide-retroinversion of formula (I), having a reverse amino acid sequence with the replacement of L-form amino acids to D-form and D-form amino acids to L-form, of the general formula (II) [SEQ ID NO:
- 2]
- D-Thr*-XDL4-D-Leu-D-Lys-XDL5-XDL6-XDL7-R2 (II)
- wherein:
- XDL4—one of the amino acids:
- D-Gln, D-Ala or L-Ala;
- XDL5—one of the amino acids:
- D-His, L-His, D-Ala or L-Ala,
- XDL6—one of the amino acids:
- D-Leu, D-Ala or L-Ala,
- XDL7—the absence of an amino acid or D-Tyr,
- R2—OMe or NH2,
- to a subject in need thereof.
Method of preventing or treating a disease or condition in an animal comprising administering an effective amount of synthetic peptides of general formula (I) [SEQ ID NO:
- 1] or general formula (II) [SEQ ID NO:
- 2] or a prodrug thereof, or a physiologically acceptable salt or solvate of the aforementioned peptides or pharmaceutical composition containing the above peptides as specific inhibitors of clathrin.
Dependencies are inferred from the claim text.