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US 2022/0087947 A1Published application
Nanoparticle for delivering ribonucleoprotein and use thereof
AssigneeKorea Institute of Science and Technology
InventorsHyojin LEE, Seongchan KIM, Youngdo JEONG
Life of this patent
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Abstract
Provided are a surface-aminated mesoporous silica nanoparticle, a method of preparing the same, use of the nanoparticle for delivering a ribonucleoprotein, and use of the nanoparticle for the prevention or treatment of cancer. The surface-aminated mesoporous silica nanoparticle may be loaded with large RNPs such as Cas9-RNP, and thus may be applied to treatment of various diseases treatable by gene editing.
Claims19
A surface-aminated mesoporous silica nanoparticle which has a mean pore size of about 15 nm to about 50 nm and is capable of being loaded with ribonucleoprotein (RNP).
Dependencies are inferred from the claim text.