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US 2022/0064600 A1Published application
Methods of expanding myeloid cell populations and uses thereof
AssigneeCellerant Therapeutics, Inc.
InventorsTimothy C. FONG, Adrianus Geertrudis Wilhelmus DOMEN, Julie Lynne CHRISTENSEN
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Abstract
The present disclosure relates to a method of expanding myeloid progenitor cells by culturing an initial population of cells in a medium comprising a mixture of cytokines and growth factors that promote growth and expansion of the myeloid progenitor cells. The expanded cell population provides a source of cells as therapeutic treatments for neutropenia and/or thrombocytopenia arising in patients subjected to myeloablative therapy and hematopoietic stem cell transplantation.
Claims18
A method of improving impaired hematopoiesis in a human, comprising,
- administering to the human a composition comprising human allogeneic myeloid progenitor cells derived from multiple unrelated donors in an amount sufficient to improve hematopoiesis in the human, wherein there is at least a partial mismatch at a major histocompatability complex (MHC) gene between the donors and the human.
Dependencies are inferred from the claim text.