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US 2022/0064323 A1Published application
Therapeutic Anti-CD9 Antibody
AssigneeAimm Therapeutics B.V.
InventorsHergen SPITS, Paula Maria Wilhelmina VAN HELDEN, Remko SCHOTTE, Wouter POS, Christien FATMAWATI, Danïel Michiel GO, Koen WAGNER, Julien Christian VILLAUDY
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Abstract
The present invention provides novel binding compounds and therapeutic applications thereof.
Claims20
-50. (canceled)
A method for at least in part treating or preventing a disorder associated with CD9-expressing cells, comprising administering to an individual in need thereof a therapeutically effective amount of an antibody or functional part or functional equivalent that comprises:
- a heavy chain CDR1 sequence that has at least 80% sequence identity with the sequence DYAMH (SEQ ID NO:2), and
- a heavy chain CDR2 sequence that has at least 80% sequence identity with the sequence GISWNSGSIVYADSVKG (SEQ ID NO:4), and
- a heavy chain CDR3 sequence that has at least 80% sequence identity with the sequence AVSGYYPYFDY (SEQ ID NO:6), and
- a light chain CDR1 sequence that has at least 80% sequence identity with the sequence KSSQSVLYSSNNKNYLG (SEQ ID NO:8), and
- a light chain CDR2 sequence that has at least 80% sequence identity with the sequence WASTRES (SEQ ID NO:10), and
- a light chain CDR3 sequence that has at least 80% sequence identity with the sequence QQYYTTP (SEQ ID NO:12);
- or administering to said individual a nucleic acid molecule or functional equivalent encoding said antibody or functional part or functional equivalent, or a vector comprising said nucleic acid molecule or functional equivalent, or an isolated or recombinant cell comprising said nucleic acid molecule or functional equivalent, or a composition comprising said antibody or functional part or functional equivalent, or a composition comprising said nucleic acid molecule or functional equivalent, or a composition comprising said vector or said cell.
4 more elements
-57. (canceled)
-72. (canceled)
Dependencies are inferred from the claim text.