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AssigneeJanssen Biotech, Inc.
InventorsEllen CHI, Wilson EDWARDS, Matt HUSOVSKY, Ann LACOMBE, Christian MARTINEZ, H. Mimi ZHOU, John T. LEE
Estimating the term…
In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.
An anti-idiotype antibody or antigen-binding portion thereof that specifically binds a target antibody that comprises GP5B83.
An anti-idiotype antibody or an antigen-binding portion thereof that specifically binds GP5B83, wherein the anti-idiotype antibody or antigen-binding portion comprises a heavy chain variable (VH) domain comprising a VH CDR1 having an amino acid sequence selected from the group consisting of SEQ ID NOs:4-7, a VH CDR2 having an amino acid sequence selected from the group consisting of SEQ ID NOs:11-14 and a VH CDR3 having an amino acid sequence selected from the group consisting of SEQ ID NOs:19-20, and further comprises a light chain variable (VL) domain comprising a VL CDR1 having an amino acid sequence selected from the group consisting of SEQ ID NOs:25-26, a VL CDR2 having an amino acid sequence selected from the group consisting of SEQ ID NOs:29-30 and a VL CDR3 having an amino acid sequence selected from the group consisting of SEQ ID NO:33-34.
A nucleic acid encoding the heavy chain, the light chain, or both, of an anti-idiotype antibody or an antigen-binding portion thereof that specifically binds GP5B83, wherein said nucleic acid comprises:
Dependencies are inferred from the claim text.