Antibodies and methods for treatment of lyssavirus infection
OwnerDavide CORTI, Hervé BOURHY +3inventors
InventorsDavide CORTI, Hervé BOURHY, Florian SONTHONAX, Gabriel LEPOUSEZ, Guilherme DIAS DE MELO
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Abstract
The invention provides antibodies, and antigen-binding fragments thereof, that potently neutralize lyssavirus infection and the use of such antibodies. In particular, the invention provides methods of treatment of lyssavirus infection, such as rabies.
Claims50
A method of treating a lyssavirus infection in a subject, the method comprising administering an anti-lyssavirus antibody, or an antigen-binding fragment thereof into a central nervous system (CNS) and peripherally.
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An anti-lyssavirus antibody, or an antigen-binding fragment thereof, comprising an Fc moiety comprising a CH2 domain and a CH2 L4A mutation and/or a CH2 L5A mutation.
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A method of treating a lyssavirus infection in a subject, the method comprising administering an anti-lyssavirus antibody, or an antigen-binding fragment thereof, into a central nervous system of the subject, wherein the subject has been administered, is being administered, or will be administered the anti-lyssavirus antibody, or an antigen-binding fragment thereof peripherally.
A method of treating a lyssavirus infection in a subject, the method comprising administering an anti-lyssavirus antibody, or an antigen-binding fragment thereof, peripherally in the subject, where the anti-lyssavirus antibody, or antigen-binding fragment thereof has been administered, is being administered, or will be administered into a central nervous system (CNS) of the subject.
Dependencies are inferred from the claim text.