Branched receptor binding multi-subunit protein complexes for use in bacterial delivery vehicles
AssigneeEligo Bioscience
InventorJesus Fernandez Rodriguez
Life of this patent
Estimating the term…
Abstract
The present disclosure relates generally to bacterial delivery vehicles for use in efficient transfer of a desired payload into a target bacterial cell. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges based on the presence of a chimeric receptor binding protein (RBP) composed of a fusion between the N-terminal region of a RBP derived from a lambda-like bacteriophage and the C-terminal region of a different RBP, and/or the presence of an engineered branched receptor binding multi-subunit polypeptides (“branched-RBP”).
Claims29
An engineered branched receptor binding multi-subunit protein complex (branched-RBP) comprising two or more associated bacteriophage derived receptor binding proteins (RBP):
- wherein a first associated bacteriophage derived receptor binding protein comprises a first interaction domain (ID);
- and
- wherein a second associated bacteriophage derived receptor binding protein comprises a second interaction domain.
A bacterial delivery vehicle comprising an engineered branched-RBP.
Dependencies are inferred from the claim text.