Substituted imidazoles for the inhibition of tgf-beta and methods of treatment

A compound of Formula (I):

• or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein:
• R1 is:
• a hydrogen atom;
• a halogen atom;
• an alkyl group containing 1 to 6 carbon atoms;
• an alkyl group containing 1 to 6 carbon atoms, substituted with a cycloalkyl group containing 3 to 7 carbon atoms;
• an alkyl group containing 1 to 6 carbon atoms, substituted with 2 to 7 halogens;
• an alkenyl group containing 1 to 6 carbon atoms;
• an alkynyl group containing 1 to 6 carbon atoms;
• a cycloalkyl group containing 3 to 7 carbon atoms;
• a phenyl group;
• a phenyl group substituted with an alkyl group containing 1 to 6 carbons;
• a phenyl group with an alkyl group containing 1 to 6 carbons, optionally further substituted with a hydroxyl group, an alkoxy group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms substituted with an alkoxy group containing 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms substituted with an alkylamino group containing 1 to 6 carbon atoms;
• a carboxylic acid group;
• a carboxylic ester group;
• a carboxamide group;
• or
• C(O)R5;
• R2 is:
• a hydrogen atom;
• a halogen atom;
• an alkyl group containing 1 to 6 carbon atoms;
• an alkyl group containing 1 to 6 carbon atoms, substituted with a cycloalkyl group containing 3 to 7 carbon atoms, or a cycloalkyl group containing 1 to 3 heteroatoms selected from the group consisting of 0, N, and S;
• an alkyl group containing 1 to 6 carbon atoms, substituted with 2 to 7 halogens;
• an alkyl group containing 1 to 6 carbon atoms, substituted with 1 to 2 heteroatoms selected from the group consisting of 0, N, and S;
• an alkenyl group containing 1 to 6 carbon atoms;
• an alkynyl group containing 1 to 6 carbon atoms;
• a cycloalkyl group containing 3 to 7 carbon atoms;
• a phenyl group;
• or
• a phenyl group substituted with an alkyl group containing 1 to 6 carbons;
• R3 is:
• a phenyl group;
• a phenyl group substituted with 1 to 5 members selected from a group consisting of a halogen, an alkyl group containing 1 to 6 carbon atoms, an alkenyl group containing 1 to 6 carbon atoms, an alkynyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, a phenyl group, a pyridyl group, a hydroxyl group, an amido group, a carbamoyl group, or a cyano group;
• an unsubstituted heteromonocyclic group;
• an unsubstituted heterobicyclic group;
• a heteromonocyclic or a heterobicyclic group substituted with 1 to 5 members selected from a group consisting of a halogen and an alkyl group containing 1 to 6 carbon atoms, optionally substituted with a cycloalkyl group containing 3 to 7 carbon atoms or a cycloalkyl group containing 1 to 3 heteroatoms selected from the group consisting of 0, N, and S;
• a phenyl group, a pyridyl group, an alkoxy group containing 1 to 6 carbon atoms, a hydroxyl group, a hydroxyalkyl group, an alkylsulfonyl group, an alkylsulfinyl group, an arylsulfonyl group, an arylsulfinyl group, a cycloalkylsulfonyl group, a cycloalkylsulfinyl group, a heterocyclosulfonyl group, a heterocyclosulfinyl group, an amino group, an amido group, a carbamoyl group, a cyano group, an aryl group substituted with a carbamoyl group, a sulfonyl group, a hydroxyalkyl group, a heteroaryl group substituted with a primary amide group, a secondary amide group, a tertiary amide group, a cyclic secondary amide group, a cyclic tertiary amide group, a sulfonyl group, or a hydroxyalkyl group, wherein the sulfonyl group or hydroxyalkyl group is optionally further substituted with at least one of the group consisting of R5 and R6, an alkenyl group containing 1 to six carbon atoms, wherein the alkenyl group is optionally further substituted with an amido group;
• R4 is:
• a hydrogen atom;
• an alkyl group containing 1 to 12 carbon atoms;
• an alkyl group containing 1 to 12 carbon atoms substituted with an alkoxy group containing 1 to 6 carbon atoms, a hydroxyl group, an alkoxyphenylalkoxy group having 8 to 12 carbon atoms, a morpholino group, a piperidinyl group, a pyrrolidino group, or a cyclic ether group containing 3 to 6 carbon atoms;
• an alkyl group having 1 to 6 carbon atoms substituted with 1 to 7 halogen atoms;
• an alkenyl group containing 1 to 6 carbon atoms;
• an alkynyl group containing 1 to 6 carbon atoms;
• a cycloalkyl group containing 3 to 7 carbon atoms;
• a cycloalkyl group containing 3 to 9 carbon atoms substituted with 1 to 7 halogens, or an oxo group;
• a cyclic ether containing 3 to 6 carbon atoms;
• or
• a 4-piperidinyl group;
• R5 is:
• an alkyl group having 1 to 6 carbon atoms;
• a cycloalkyl group containing 3 to 7 carbon atoms optionally substituted with 1 to 7 halogens, an aryl group, or a heteroaryl group;
• R6 is:
• an alkyl group having 1 to 6 carbon atoms;
• a cycloalkyl group containing 3 to 7 carbon atoms, an aryl group, or a heteroaryl group;
• X is:
• CH2, CH, C, O, S, or N;
• n is:
• 0-2;
• and
• y is:
• a single or double bond.