Antigen-specific t cells for inducing immune tolerance
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsDavid W. SCOTT, Yongchan KIM, Aihong ZHANG
Life of this patent
Estimating the term…
Abstract
Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or bi-specific antibodies. The agents and methods can be used to reduce undesirable immune responses.
Claims17
A method of targeting antigen-specific B cells, comprising exposing B cells specific to a target antigen to regulatory T cells that express on their cell surface the target antigen or a domain thereof recognized by said antigen-specific B cells.
-5. (canceled)
-8. (canceled)
-11. (canceled)
-16. (canceled)
(canceled)
-39. (canceled)
Dependencies are inferred from the claim text.