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US 2022/0054455 A1Published application
Sustained-release pharmaceutical compositions comprising of a sedative drug and uses thereof
AssigneesTaiwan Liposome Co., Ltd., Tlc Biopharmaceuticals, Inc.
InventorsKeelung HONG, Walter GWATHNEY, Hao-wen KAO, Yi-yu LIN
Life of this patent
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Abstract
The present invention relates to a pharmaceutical composition comprising at least one liposome, a trapping agent and a sedative drug with a high drug to lipid ratio and a high encapsulation efficiency. Also provided are the methods to sedate or treat pain in a subject in need thereof by administering the pharmaceutical composition disclosed herein.
Claims22
A pharmaceutical composition, comprising
- (a) a first liposome comprising a bilayer membrane, said bilayer membrane comprises at least one lipid;
- (b) a trapping agent;
- and
- (c) a sedative drug,
- wherein the molar ratio of the drug to the lipid is equal to or higher than about 0.02.
2 more elements
A method for sedating a subject, comprising:
- administering a pharmaceutical composition to the subject in need of sedation, said pharmaceutical composition comprising:
- (a) at least one first liposome comprising a bilayer membrane, bilayer membrane comprises at least one lipid;
- (b) a trapping agent;
- and
- (c) a sedative drug,
- wherein the molar ratio of the drug to the lipid is equal to or higher than about 0.02.
3 more elements
20-22. (canceled)
A method for treating pain a subject, comprising:
- administering a pharmaceutical composition to the subject in need thereof, said pharmaceutical composition comprising:
- (a) a first liposome comprising a bilayer membrane, a trapping agent, and a sedative drug;
- wherein the bilayer membrane comprises at least one lipid and the molar ratio of the drug to the lipid is equal to or higher than about 0.02, and
- (b) an anesthetic, an analgesic or a combination thereof.
1 more element
24-28. (canceled)
Dependencies are inferred from the claim text.