US 2022/0044835 A1 · PROCESSES AND SYSTEMS FOR PRODUCING AND/OR PURIFYING GALLIUM-68

Abstract

The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.

Claims22

Dependent claims

A process for purifying 68Ga produced by cyclotron, the process comprising the steps of:

(a) providing a solution comprising a mixture of 68Zn and 68Ga;
(b) contacting the solution with a first chelating cation exchange column, the first chelating cation exchange column comprising a hydroxamate resin;
(c) washing the first chelating cation exchange column obtained after step (b) to obtain a washed first chelating cation exchange column;
(d) eluting the 68Ga from the washed first chelating cation exchange column to obtain a first eluent;
(e) contacting the first eluent with a second copolymeric cation exchange column, the second copolymeric cation exchange column comprising a resin;
(f) washing the second copolymeric cation exchange column after step (e) to obtain a washed second copolymeric cation exchange column;
and
(g) eluting the 68Ga from the washed second copolymeric cation exchange column to obtain a second eluent comprising purified 68Ga.

5 more elements

Dependencies are inferred from the claim text.

Processes and systems for producing and/or purifying gallium-68

Life of this patent

Processes and systems for producing and/or purifying gallium-68

Life of this patent

Abstract

Claims22