Device and method for localising or identifying malignancies

A method for treatment of a malignancy in a patient, comprising:

• providing a sample from a patient comprising serum albumin;
• combining, in aliquots of the sample, a spin probe and a polar reagent comprising alcohol or dimethyl sulfoxide (DMSO), wherein at least one of the concentration of the spin probe and the concentration of the polar reagent varies between the aliquots;
• detecting a plurality of electron spin resonance spectroscopy (ESR) spectra from the aliquots;
• determining from the plurality of ESR spectra, a plurality of biophysical parameters selected from the group consisting of:
• a spectral component from spin probe bound to albumin with a high binding affinity;
• a spectral component from spin probe bound to albumin with a low binding affinity;
• a spectral component from free spin probe molecules;
• a spectral components from free spin probe in micelles;
• and a spectral component from spin probe on lipid-fraction of serum;
• applying the determined biophysical parameters, or parts thereof, as an input to a trained logistic regression model, the logistic regression model trained to determine a probability of applied input parameters relating to one or more of a plurality of predetermined malignancies and locations thereof;
• determining the presence of the malignancy and location thereof from the determined probability;
• and
• providing to the patient a treatment appropriate to the determined malignancy.