Loading patent…
AssigneeIROA Technologies LLC
InventorsChristopher Beecher, Richard A. Yost, Robin Hendrikus Johannes Kemperman
Estimating the term…
An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.
An IROA Matrix composition of biologically-produced metabolite compounds, each of said metabolite compounds having a molecular weight of about 2000 AMU or less, and each of said metabolite compounds being present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, said first isotopomers containing about 2 to about 10% of a first isotope, and said second isotopomers containing about 90 to about 98% of a second isotope of the same atom, said first and second isotopes being stable to radioactive decay and other than hydrogen and deuterium.
A reagent pair capable of transforming the biologically-produced metabolite compounds of a natural abundance mass spectral analysis sample into an IROA sample that comprises two reactively identical reagents that constitute first and second isotopomers, said first isotopomers containing about 2 to about 10% of a first isotope, and said second isotopomers containing about 90 to about 98% of a second isotope of the same atom, said first and second isotopes being stable to radioactive decay and being other than hydrogen and deuterium, each of said reagent pair containing the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds, each of said metabolite compounds having a molecular weight of about 2000 AMU or less.
Dependencies are inferred from the claim text.