Back to results
US 2022/0036970 A1Published application
Methods and systems for determination of gene similarity
OwnerBiming Wu, Suganthi Balasubramanian +1inventors
InventorsBiming Wu, Suganthi Balasubramanian, Jeffrey Reid
Life of this patent
Estimating the term…
Abstract
Methods are disclosed for determining similarities between genes.
Claims22
A method comprising:
- determining, for each of a plurality of phenotypes, an association score indicative of an association between at least one variant of each gene of a plurality of genes and a phenotype of the plurality of phenotypes;
- determining, for each gene of the plurality of genes, based on the association scores, a gene-level association score indicative of a representative association between each gene of the plurality of genes and each phenotype of the plurality of phenotypes;
- generating, based on the gene-level association scores, a gene-phenotype score matrix, wherein the gene-phenotype score matrix comprises, for each gene of the plurality of genes, the gene-level association score for each phenotype of the plurality of phenotypes;
- receiving a selection of a gene-of-interest;
- determining, based on the selection, in the gene-phenotype score matrix, gene-level association scores of the gene-of-interest;
- determining, in the gene-phenotype score matrix, one or more genes associated with gene-level association scores similar to the gene-level association scores of the gene-of-interest;
- and
- identifying a gene of the one or more genes as a gene associated with the gene-of-interest.
5 more elements
A method comprising:
- determining, for each of a plurality of phenotypes, an association score indicative of an association between at least one variant of each gene of a plurality of genes and a phenotype of the plurality of phenotypes;
- determining, for each gene of the plurality of genes, based on the association scores, a gene-level association score indicative of a representative association between each gene of the plurality of genes and each phenotype of the plurality of phenotypes;
- and
- generating, based on the gene-level association scores, a gene-phenotype score matrix, wherein the gene-phenotype score matrix comprises, for each gene of the plurality of genes, the gene-level association score for each phenotype of the plurality of phenotypes.
1 more element
A method comprising:
- receiving a selection of a gene-of-interest;
- determining, based on the selection, in a gene-phenotype score matrix, gene-level association scores of the gene-of-interest, wherein the gene-phenotype score matrix comprises, for each gene of a plurality of genes, a gene-level association score for each phenotype of a plurality of phenotypes;
- determining, in the gene-phenotype score matrix, one or more genes associated with gene-level association scores similar to the gene-level association scores of the gene-of-interest;
- and
- identifying a gene of the one or more genes as a gene associated with the gene-of-interest.
2 more elements
Dependencies are inferred from the claim text.