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US 2022/0034868 A1Published application
Cardiotoxicity assessment method
AssigneeZeon Corporation
InventorsSatoru ADACHI, Yuko SEKINO
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Abstract
Provided is a cardiotoxicity assessment method which comprises: seeding cardiomyocytes in a culture container together with a culture medium; adding a drug to the culture medium in the culture container to bring the drug into contact with the cardiomyocytes; and measuring a heart disease biomarker secreted from the cardiomyocytes to assess cardiotoxicity of the drug, wherein at least a culture surface of the culture container is composed of an alicyclic structure-containing polymer, and the culture surface has a surface free energy of 30 to 37 mN/m.
Claims8
A cardiotoxicity assessment method comprising:
- seeding cardiomyocytes in a culture container together with a culture medium;
- adding a drug to the culture medium in the culture container to bring the drug into contact with the cardiomyocytes;
- and
- measuring a heart disease biomarker secreted from the cardiomyocytes to assess cardiotoxicity of the drug,
- wherein at least a culture surface of the culture container is composed of an alicyclic structure-containing polymer, and the culture surface has a surface free energy of 30 to 37 mN/m.
2 more elements
Dependencies are inferred from the claim text.