Diagnosis of tuberculosis and other diseases using exhaled breath
AssigneeZeteo Tech, Inc.
InventorsDapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Abstract
Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.
Claims27
A system for diagnosing respiratory diseases in an individual using exhaled breath, the system comprising:
- a sample collection system comprising:
- a sample extraction component configured to receive an individual's face for extracting breath aerosol (EBA) particles expelled from the individual during a predetermined number of breath maneuvers into a flow of air fed into the extraction component;
- a sample capture component comprising:
- means to collect the EBA particles into a collected liquid sample;
- and,
- a packed bed column to selectively capture the EBA particles from the collected liquid sample onto the packed bed;
- means to elute the collected EBA particles from the packed bed using one or more solvents;
- and,
- a diagnostic device for analyzing the EBA particles comprised in the one or more solvents.
A method for diagnosing respiratory diseases in an individual using exhaled breath, the method comprising:
- extracting EBA particles expelled into a flow of air fed into a sample extraction component configured to receive an individual's face;
- collecting the EBA particles from exhaled breath and air as a collected liquid sample;
- capturing the EBA particles in the collected liquid sample using a packed bed column to selectively capture the EBA particles from the collected liquid sample onto the packed bed;
- and,
- eluting the collected EBA particles from the packed bed using one or more solvents;
- and,
- analyzing the EBA particles comprised in the one or more solvents.
Dependencies are inferred from the claim text.