Loading patent…
AssigneesThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Children's Medical Center Corporation
InventorsAlbert DOBI, Gyorgy PETROVICS, Shiv K. SRIVASTAVA, Hua LI, Zoltan SZALLASI
Estimating the term…
The present disclosure provides methods of identifying or characterizing prostate cancer comprising detecting in a biological sample the presence or absence of a genomic rearrangement that results in a deletion of an LSAMP gene and detecting in a biological sample the presence or absence of a genomic rearrangement that results in a deletion of a CHD1 gene. In certain embodiments, the patient self-identifies as being of African descent. Also disclosed herein are methods of testing for the presence of genomic rearrangements in an LSAMP gene and a CHD1 gene in a biological sample. The LSAMP and CHD1 genomic rearrangements serves as a biomarker for prostate cancer and can be used to stratify prostate cancer based on ethnicity or the severity or aggressiveness of prostate cancer and/or identify a patient for prostate cancer treatment. Also provided are kits for diagnosing and prognosing prostate cancer and methods of selecting a targeted prostate cancer treatment for a patient.
-4. (canceled)
A method of testing for the presence of genomic rearrangements in an LSAMP gene and a CHD1 gene in a biological sample obtained from a subject, the method comprising:
A kit for use in diagnosing or prognosing prostate cancer in a subject of African descent, the kit comprising at least two oligonucleotide probes, wherein the at least two oligonucleotide probes comprise a first oligonucleotide probe for detecting a first genomic rearrangement that results in a deletion of a human LSAMP gene and a second oligonucleotide probe for detecting a second genomic rearrangement that results in a deletion of a human CHD1 gene, wherein the kit contains oligonucleotide probes for detecting no more than 500 different genes.
-24. (canceled)
A method of treating a prostate cancer in a human patient, wherein the method comprises:
Dependencies are inferred from the claim text.