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AssigneesPFS Genomics, Inc., Decipher Biosciences, Inc.
InventorsS. Laura Chang, Elai Davicioni, Felix Feng
Estimating the term…
Methods, systems, and kits for the diagnosis, prognosis, and treatment of breast cancer in a subject are disclosed. The invention also provides biomarkers and clinically useful classifiers for identifying subjects at low risk of breast cancer recurrence who may be spared from adjuvant chemotherapy and endocrine therapy. Further disclosed herein, in certain instances, are probe sets for use in detecting such biomarkers for determining the risk of breast cancer recurrence in a subject. Methods of treating breast cancer based on expression profiling to determine the risk of breast cancer recurrence are also provided.
A method of treating breast cancer in a subject, comprising:
A kit for determining a prognosis of a subject having breast cancer and whether or not to treat the subject with adjuvant chemotherapy and endocrine therapy, the kit comprising agents for measuring levels of expression of a plurality of genes selected from Table 2.
A probe set for determining a prognosis of a subject having breast cancer and whether or not to treat the subject with adjuvant chemotherapy and endocrine therapy, the probe set comprising a plurality of probes for detecting a plurality of target nucleic acids, wherein the plurality of target nucleic acids comprises one or more gene sequences, or complements thereof, of genes selected from Table 2.
Dependencies are inferred from the claim text.