Methods for simultaneous amplification of target loci

A method for preparing a preparation of amplified DNA derived from one or more fetal or embryonic cells of an unborn fetus or embryo useful for reconstructing at least a portion of the genome of the fetus or embryo, comprising:

• (a) extracting genomic DNA from the one or more fetal or embryonic cells;
• (b) preparing a preparation of amplified DNA by amplification of at least 1,000 polymorphic loci from the genomic DNA extracted in (a) to obtain amplified DNA;
• (c) analyzing the amplified DNA obtained in (b) by high-throughput sequencing to obtain genetic data of the fetus or embryo at the polymorphic loci, and reconstructing at least a portion of the genome of the fetus or embryo using the genetic data of the fetus or embryo and haplotypes of at least one biological parent of the fetus or embryo at the polymorphic loci.