Mirnas as biomarkers for parkinson's syndrome
AssigneeHummingbird Diagnostics GmbH
InventorsAndreas Keller, Bruno Steinkraus
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Abstract
The present invention relates to methods for diagnosing a Parkinson's syndrome (PS), Parkinson's disease (PD), or Parkinsonism in an individual. Further, the present invention relates to a method for differential diagnosing between PD and Parkinsonism. Furthermore, the present invention relates to methods for monitoring the course of a Parkinson's syndrome, Parkinson's disease (PD), or Parkinsonism in an individual. In addition, the present invention relates to kits suitable to carry out the above described methods.
Claims20
-70. (canceled)
A method for
- (a) diagnosing a Parkinson's syndrome (PS) in an individual (suspected of having a Parkinson's syndrome), or
- (b) determining the course of a Parkinson's syndrome in an individual having a Parkinson's syndrome
- comprising the step of:
- determining the level of at least one miRNA in a biological sample isolated from the individual (suspected of having a Parkinson's syndrome),
- wherein the at least one miRNA has a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 23, and a sequence having at least 90% sequence identity thereto.
A method for
- (a) diagnosing Parkinson's disease (PD) in an individual (suspected of having PD), or
- (b) determining the course of Parkinson's disease (PD) in an individual having PD comprising the step of:
- determining the level of at least one miRNA in a biological sample isolated from the individual (suspected of having PD),
- wherein the at least one miRNA has a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 5, SEQ ID NO:
- 7 to SEQ ID NO:
- 13, SEQ ID NO:
- 16 to SEQ ID NO:
- 23, SEQ ID NO:
- 47 to SEQ ID NO:
- 59, and a sequence having at least 90% sequence identity thereto.
A method for
- (a) diagnosing Parkinsonism in an individual (suspected of having Parkinsonism), or
- (b) determining the course of Parkinsonism in an individual having Parkinsonism comprising the step of:
- determining the level of at least one miRNA in a biological sample isolated from the individual (suspected of having Parkinsonism),
- wherein the at least one miRNA has a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 5, SEQ ID NO:
- 8 to SEQ ID NO:
- 11, SEQ ID NO:
- 13, SEQ ID NO:
- 15, SEQ ID NO:
- 17, SEQ ID NO:
- 19 to SEQ ID NO:
- 21, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 32, SEQ ID NO:
- 41 to SEQ ID NO:
- 46, SEQ ID NO:
- 48, SEQ ID NO:
- 56, SEQ ID NO:
- 61, SEQ ID NO:
- 63, SEQ ID NO:
- 68, SEQ ID NO:
- 72, SEQ ID NO:
- 74 to SEQ ID NO:
- 96, SEQ ID NO:
- 107, and a sequence having at least 90% sequence identity thereto.
A method for differentiating between Parkinson's disease (PD) and Parkinsonism comprising the step of:
- determining the level of at least one miRNA in a biological sample isolated from an individual (having a Parkinson's syndrome),
- wherein the at least one miRNA has a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 8, SEQ ID NO:
- 11, SEQ ID NO:
- 17, SEQ ID NO:
- 37, SEQ ID NO:
- 42, SEQ ID NO:
- 45, SEQ ID NO:
- 60, SEQ ID NO:
- 70, SEQ ID NO:
- 76, SEQ ID NO:
- 77, SEQ ID NO:
- 84, SEQ ID NO:
- 88, SEQ ID NO:
- 93, SEQ ID NO:
- 97 to SEQ ID NO:
- 106, and a sequence having at least 90% sequence identity thereto.
Dependencies are inferred from the claim text.