A modular, polycistronic vector for car and tcr transduction
AssigneeBoard of Regents, The University of Texas System
InventorsKaty Rezvani, Elizabeth Shpall
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Abstract
Provided herein is a modular polycistronic vector system, such as for the genetic reprogramming of cells to express one or more antigen receptors. The modular characteristic of the system allows for exchange of one or more cistrons in addition to one or more components within particular cistrons. In specific embodiments, the modularity of the system allows exchange of components of a chimeric antigen receptor, such as exchange of costimulatory domains, scFvs, hinges, signaling domains, and so forth.
Claims64
A polycistronic vector comprising at least three cistrons each flanked by one or more restriction enzyme sites, wherein at least one cistron encodes for at least one antigen receptor.
A polycistronic vector comprising at least four cistrons each flanked by one or more restriction enzyme sites, wherein at least one of the cistrons on the vector comprises two or more modular components, wherein each of the modular components within a cistron is flanked by one or more restriction enzyme sites.
Dependencies are inferred from the claim text.