Functionalization of endogenous bacteria
AssigneesTrustees of Boston University, Massachusetts Institute of Technology
InventorsTimothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
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Abstract
Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
Claims21
-21. (canceled)
A recombinant bacteriophage that is engineered for in vivo delivery to endogenous bacterial cells to contain at least one genetic circuit, wherein the at least one genetic circuit does not express an antimicrobial protein.
-76. (canceled)
Dependencies are inferred from the claim text.