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US 2022/0033772 A1Published application
Factor rich products from umbilical cord mesenchymal stem cells
AssigneeRestem LLC
InventorsRafael Gonzalez, Toai Nguyen
Life of this patent
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Abstract
Factor rich compositions produced from umbilical cord (UC) mesenchymal stem cells (MSCs) are described. Secretory UC MSCs in serum free culture conditions produce a factor rich conditioned medium which may be concentrated and filtered to obtain clinical grade products.
Claims6
A factor rich composition derived from umbilical cord (UC) mesenchymal stem cells (MSCs) cultured without serum or exogenous growth factors comprising:
- a. a population of exosomes at a concentration of at least 22 billion per milliliter (ml);
- b. said population of exosomes at an average size of about 133.4 nanometers (nm);
- c. a growth factor selected from the group consisting of stem cell factor (SCF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF) and combinations thereof;
- d. said growth factors at a concentration of at least 20-2000 picogram (pg)/ml;
- e. a cytokine or chemokine selected from the group consisting of interferon gamma, (INF-γ), interleukins (IL) 3, 6, 18, IL-4 7, 8, macrophage inflammatory protein-1 beta (MIP1β), monocyte chemoattractant protein-1 (MCP1) and tumor necrosis factor alpha (TNFα) and combinations thereof;
- f. a glycosaminoglycan (GAG) selected from the group consisting of hyaluronic acid (HA) and chondroitin sulfate (CS);
- g. a collagen selected from the group consisting of collagen I and collage III.
4 more elements
Dependencies are inferred from the claim text.