Antibody binding to carbonic anhydrase and use thereof
AssigneeAprogen Kic Inc.
InventorsYoo Ri MOON, Sangsoon Yoon, Jeong Won Hong, Eun Jung Kim, Da Bin Choi
Life of this patent
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Abstract
Provided is an antibody that recognizes and binds to carbonic anhydrase or antigen-binding fragment, a nucleic acid molecule coding for the antibody or antigen-binding fragment, a vector carrying the nucleic acid molecule, a host cell including the nucleic acid molecule or the vector, and use of the antibody or antigen-binding fragment thereof in the alleviation, prevention, treatment or diagnosis of solid cancers.
Claims17
A method of preventing, alleviating or treating a solid cancer, comprising administering an effective amount of an antibody or antigen-binding fragment to a subject in need of preventing, alleviating or treating the solid cancer,
- wherein the antibody or antigen-binding fragment comprises a VH-CDR1 having the amino acid sequence of SEQ ID NO:
- 14, a VH-CDR2 having the amino acid sequence of SEQ ID NO:
- 15, a VH-CDR3 having the amino acid sequence of SEQ ID NO:
- 28, a VL-CDR1 having the amino acid sequence of SEQ ID NO:
- 32 or 33, a VL-CDR2 having the amino acid sequence selected from the group consisting of SEQ ID NO:
- 34 to 42, and a VL-CDR3 having the amino acid sequence of SEQ ID NO:
- 31.
A method of detecting a solid cancer, comprising contacting an antibody or antigen-binding fragment to a sample,
- wherein the sample is determined as the solid cancer if the sample shows a positive reaction to the antibody or antigen-binding fragment,
- wherein the antibody or antigen-binding fragment comprises a VH-CDR1 having the amino acid sequence of SEQ ID NO:
- 14, a VH-CDR2 having the amino acid sequence of SEQ ID NO:
- 15, a VH-CDR3 having the amino acid sequence of SEQ ID NO:
- 28, a VL-CDR1 having the amino acid sequence of SEQ ID NO:
- 32 or 33, a VL-CDR2 having the amino acid sequence selected from the group consisting of SEQ ID NO:
- 34 to 42, and a VL-CDR3 having the amino acid sequence of SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.