Multispecific antibodies
AssigneeGenentech, Inc.
InventorsGermaine FUH, Jenny M. BOSTROM
Life of this patent
Estimating the term…
Abstract
The invention provides multispecific antibodies and methods of making and using such antibodies.
Claims16
1-44. (canceled)
A multispecific antibody capable of binding to a first epitope on VEGF and a second epitope on HER2, wherein the multispecific antibody comprises an antigen-binding site comprising a light chain variable domain (VL) comprising the following complementarity determining regions (CDRs):
- (a) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 24,
- (b) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 25, and
- (c) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 26, and
- a heavy chain variable domain (VH) comprising the following CDRs:
- (d) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- (e) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 2, and
- (f) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 3, and
- wherein the antigen-binding site is capable of binding to the first epitope and the second epitope.
A multispecific antibody capable of binding to a first epitope on VEGF and a second epitope on HER2, wherein the multispecific antibody comprises an antigen-binding site comprising a light chain variable domain (VL) comprising the following complementarity determining regions (CDRs):
- (a) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 27,
- (b) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 28, and
- (c) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 26, and
- a heavy chain variable domain (VH) comprising the following CDRs:
- (d) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- (e) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 2, and
- (f) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 3, and
- wherein the antigen-binding site is capable of binding to the first epitope and the second epitope.
A multispecific antibody capable of binding to a first epitope on VEGF and a second epitope on HER2, wherein the multispecific antibody comprises an antigen-binding site comprising a light chain variable domain (VL) comprising the following complementarity determining regions (CDRs):
- (a) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 280,
- (b) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 28, and
- (c) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 26, and
- a heavy chain variable domain (VH) comprising the following CDRs:
- (d) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- (e) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 2, and
- (f) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 3, and
- wherein the antigen-binding site capable of binding to the first epitope and the second epitope.
Dependencies are inferred from the claim text.