US 2022/0033501 A1Published application

Anti-human tim-3 monoclonal antibody and application thereof

AssigneesShanghai Pharmaexplorer Co., Ltd., Pharmaexplorer Limited

InventorsNingning SONG, Qing DUAN, Lile LIU, Tatchi Teddy YANG, Lina XU, Hu LIU, Peipei WEI, Qian WANG, Yuangdong WANG, Xiaohui SHAO, Shaoping HU, Yu ZHANG, Jian WU, Meilling WANG, Dongxu WANG, Chaohui DAI, Mengying WANG

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

Provided are a high-affinity full human monoclonal antibody highly specifically targeting to TIM-3 and a preparation method therefor. The monoclonal antibody has a remarkable antitumor activity, and can be used for preparing a related diagnostic reagent or a pharmaceutical composition preventing or treating diseases related to TIM-3 dysfunction.

Claims17

Dependent claims

A heavy chain variable region of an antibody, wherein the heavy chain variable region comprises the following three complementarity determining regions or CDRs:

VH-CDR1 shown in SEQ ID NO. 10n+3,
VH-CDR2 shown in SEQ ID NO. 10n+4, and
VH-CDR3 shown in SEQ ID NO. 10n+5;
wherein each n is independently 0, 1, 2, 3, 4, 5 or 6;
wherein any one of the above amino acid sequences further comprises a derivative sequence which is obtained through optional addition, deletion, modification and/or substitution of at least one amino acid and is capable of retaining the binding affinity to TIM-3.

2 more elements

Dependencies are inferred from the claim text.