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US 2022/0033497 A1Published application
Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsMichael A. Meehl, Philip E. Brandish, Laurence Fayadat-Dilman, Veronica Juan, Carl Mieczkowski, Latika Singh
Life of this patent
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Abstract
Humanized, non-promiscuous monoclonal antibodies specific for immunoglobulin-like transcript 3 (ILT3), also known as Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), are described.
Claims13
-17. (canceled)
A chimeric, humanized, or recombinant human antibody or antigen binding fragment that binds to an epitope on a human immunoglobulin-like transcript 3 (ILT3), wherein the epitope comprises one or more of the amino acid sequences set forth in SEQ ID NOs:
- 3, 4, 5, 6, 7, and 8,
- as determined by hydrogen deuterium exchange mass spectrometry (HDX-MS) analysis.
-30. (canceled)
Dependencies are inferred from the claim text.