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US 2022/0033493 A1Published application
Compositions and methods for genetically-encoded high voltage-activated calcium channel blockers using engineered ubiquitin ligases
AssigneeThe Trustees of Columbia University in the City of New York
InventorsTravis Morgenstern, Henry M Colecraft
Life of this patent
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Abstract
The present disclosure provides, inter alia, nanobodies targeting a CaVβ auxiliary subunit and compositions thereof. Methods for blocking a High-Voltage Activated Calcium Channel (HVACC) using such compositions, methods for selectively targeting a population of cells in a subject, and methods for treating or ameliorating the effects of a disease in a subject are also provided.
Claims49
A nanobody capable of binding to a CaVβ auxiliary subunit, comprising SEQ ID NOs:
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Dependencies are inferred from the claim text.