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US 2022/0033492 A1Published application
Anti-connexin antibody formulations
AssigneeAlaMab Therapeutics, Inc.
InventorYanfeng Zhang
Life of this patent
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Abstract
The present disclosure relates to pharmaceutical compositions and methods for treating a disease or condition associated with opening of Cx43 hemichannels in astrocytes or osteocytes, preferably for treating an inflammatory disease or condition or a neurodegenerative disease such as spinal cord injury.
Claims20
A pharmaceutical formulation comprising:
- an anti-Cx43 antibody or antigen binding fragment thereof;
- a buffer;
- a surfactant;
- and
- a stabilizer;
- wherein the pharmaceutical formulation has a pH of between about 5 and about 6;
- wherein the anti-Cx43 antibody or antigen binding fragment thereof comprises:
- a first, second and third heavy chain complementarity determining region (CDR) sequence having the amino acid sequence of SEQ ID NOs:
- 1, 2, and 3, respectively;
- and
- a first, second and third light chain CDR sequence having the amino acid sequence of SEQ ID NOs:
- 4, 5, and 6, respectively.
9 more elements
A pharmaceutical formulation comprising:
- about 40-60 mg/mL, preferably about 50 mg/mL of an anti-Cx43 antibody or antigen binding fragment thereof;
- about 10-40 mM, preferably about 20 mM histidine/histidine hydrochloride buffer;
- about 0.005%-0.05%, preferably about 0.02% w/v Polysorbate 80;
- and
- about 1%-20% w/v, preferably about 8% w/v sucrose;
- wherein the formulation has a pH of between about 5.4 to about 5.6, preferably about 5.5.
3 more elements
A pharmaceutical formulation comprising:
- about 50 mg/mL an anti-Cx43 antibody or antigen binding fragment thereof, comprising a heavy chain having an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 9-17, and comprising a light chain having the amino acid sequence of SEQ ID NO:
- 18;
- about 20 mM histidine/aspartic acid buffer;
- about 0.02% w/v Polysorbate 80;
- and
- about 8% w/v sucrose,
- wherein the formulation has a pH of between about 5.4 to about 5.6, preferably about 5.5.
5 more elements
Dependencies are inferred from the claim text.