Methods and compositions for treating cancer using chrna6 inhibitors
AssigneeFlagship Pioneering Innovations V, Inc.
InventorsAvak KAHVEJIAN, Jordi MATA-FINK, Jonathan Barry HUROV, Chengyi Jenny SHU, Manuel Andreas FANKHAUSER, Julian Alexander STANLEY
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Abstract
The present invention provides methods for treating cancer using a6*nAChR inhibitors, such as a6*nAChR inhibitory antibodies, among others. The invention also features compositions containing a6*nAChR inhibitors, methods of diagnosing patients with a6*nAChR-associated cancer, and methods of predicting the response of cancer in a subject to treatment with a6*nAChR inhibitors.
Claims21
1-123. (canceled)
A method comprising administering to a subject an α6-containing nicotinic acetylcholine receptor (α6*nAChR) inhibitor, wherein the subject has a tumor comprising tumor infiltrating regulatory T cells (Tregs) that express α6*nAChR.
A method comprising administering to a subject an α6*nAChR inhibitor, wherein the subject has a cancer comprising tumor infiltrating Tregs that express α6*nAChR, and wherein the α6*nAChR inhibitor is administered in an amount effective to increase CD8+ T cell secretion of IFNγ by at least 1.1 fold, relative to a control.
A method comprising contacting a tumor comprising tumor infiltrating Tregs that express α6*nAChR with an α6*nAChR inhibitor in an amount effective to increase CD8+ T cell activation by at least 1.1 fold, relative to a control.
Dependencies are inferred from the claim text.