Anti-igf-i receptor humanized antibody

An anti-IGF-I receptor humanized antibody or its fragment or a derivative thereof comprising:

• as a sequence of CDR-1 of the heavy chain variable region (CDR-H1), the amino acid sequence defined in SEQ ID NO:1, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:1 via substitution of one amino acid residue;
• as a sequence of CDR-2 of the heavy chain variable region (CDR-H2), the amino acid sequence defined in SEQ ID NO:2, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:2 via substitution of one or two amino acid residues;
• as a sequence of CDR-3 of the heavy chain variable region (CDR-H3), the amino acid sequence defined in SEQ ID NO:3, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:3 via substitution of one or two amino acid residues;
• as a sequence of CDR-1 of the light chain variable region (CDR-L1), the amino acid sequence defined in SEQ ID NO:4, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:4 via substitution of one or two amino acid residues;
• as a sequence of CDR-2 of the light chain variable region (CDR-L2), the amino acid sequence defined in SEQ ID NO:5, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:5 via substitution of one amino acid residue;
• and
• as a sequence of CDR-3 of the light chain variable region (CDR-L3), the amino acid sequence defined in SEQ ID NO:6, or an amino acid sequence derived from the amino acid sequence defined in SEQ ID NO:6 via substitution of one or two amino acid residues;
• wherein the antibody, fragment, or derivative thereof specifically binds to an extracellular domain of SEQ ID NO:14 (human IGF-I receptor).