Compositions and methods for increasing protein half-life in a serum
AssigneeNanjing Legend Biotech Co., Ltd.
InventorsYafeng ZHANG, Shu WU, Fei SUN, Shuai YANG, Chuan-Chu CHOU
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Abstract
Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
Claims18
A polypeptide comprising at least one immunoglobulin single domain antibody (sdAb) that specifically bind human and cynomolgus monkey serum transferrin protein and protein A resin, wherein the sdAb can be purified by a protein A column and used for half-life extension fragments for short half-life proteins or fragments.
Dependencies are inferred from the claim text.