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US 2022/0033474 A1Published application
Structure-sensitive peptide antigen of von willebrand factor
AssigneeSoochow University
InventorWei DENG
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AssigneeSoochow University
InventorWei DENG
Estimating the term…
The present invention discloses a polypeptide antigen sequence, its spatially sensitive position in von Willebrand factor (VWF), and use thereof in the production of preparations for the diagnosis and/or treatment of VWF-related blood diseases. The polypeptide antigen comprises the amino acid sequence as shown in SEQ ID NO: 1, or a biologically active fragment or a variant thereof. The spatial position of the polypeptide transits from non-solvent exposure to solvent exposure when VWF is in activation process upon exposing to blood shear stress, so as to be recognized by an antibody. The antibody that recognizes the active state of VWF prepared by using the polypeptide antigen is useful in diagnosing and treating a variety of VWF-related diseases.
Use of a peptide antigen in the production of preparations for diagnosis and/or treatment of blood diseases associated with von Willebrand factor (VWF), wherein the peptide antigen comprises the amino acid sequence as shown in SEQ ID NO:
An antibody, wherein the antibody specifically recognizes a peptide antigen comprising the amino acid sequence as shown in SEQ ID NO:
Dependencies are inferred from the claim text.