Antigen receptors and uses thereof
OwnerRalf Holger VOSS, Ugur SAHIN +3inventors
InventorsRalf Holger VOSS, Ugur SAHIN, Matthias THEOBALD, Petra SIMON, Matthias BIRTEL
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Abstract
The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to recombinant antigen receptors and uses thereof. T cells engineered to express such antigen receptors are useful in the treatment of diseases characterized by expression of one or more antigens bound by the antigen receptors.
Claims19
1-60. (canceled)
An antigen receptor, which receptor comprises a first peptide chain and a second peptide chain, wherein
- the first peptide chain comprises at least a first and a second domain, and an immunoreceptor signal transmission domain;
- the second peptide chain comprises at least a first and a second domain, and an immunoreceptor signal transmission domain;
- wherein the immunoreceptor signal transmission domain is preferably of human origin,
- wherein the first domain from the first peptide chain forms together with one of the domains from the second peptide chain a first antigen binding site, and
- wherein the second domain from the first peptide chain forms together with the other domain from the second peptide chain a second antigen binding site.
A peptide chain comprising a first and a second domain which each comprise a variable region of a heavy chain of an immunoglobulin or each comprise a variable region of a light chain of an immunoglobulin and wherein the peptide chain further comprises an immunoreceptor signal transmission domain.
An ex vivo method for producing a cell expressing an antigen receptor which receptor comprises a first peptide chain and a second peptide chain, the method comprising:
- (a) providing a cell, preferably a human cell;
- (b) providing a first genetic construct encoding the first peptide chain comprising at least a first and a second domain, and an immunoreceptor signal transmission domain;
- (c) providing a second genetic construct encoding the second peptide chain comprising at least a first and a second domain and an immunoreceptor signal transmission domain;
- (d) introducing the first and second genetic constructs into the cell;
- and
- (e) allowing the constructs to be expressed in the cell;
- wherein the cell is preferably a T cell,
- wherein the first domain from the first peptide chain is able to form together with one of the domains from the second peptide chain a first antigen binding site, and
- wherein the second domain from the first peptide chain is able to form together with the other domain from the second peptide chain a second antigen binding site,
- wherein the first peptide chain and the second peptide chain are preferably provided on a single genetic construct.
Dependencies are inferred from the claim text.