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US 2022/0033455 A1Published application
Il-15-based fusions to il-7 and il-21
AssigneeAltor BioScience Corporation
InventorHing C. Wong
Life of this patent
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Abstract
The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
Claims13
1-60. (canceled)
A soluble protein complex comprising:
- a first fusion protein comprising a segment substantially identical to SEQ ID NO:
- 10 (IL-7) and a segment substantially identical to SEQ ID NO:8 (IL-15RαSu/Fc);
- and
- a second fusion protein comprising a segment substantially identical to SEQ ID NO:6 (IL-21) and a segment substantially identical to SEQ ID NO:
- 12 (IL-15N72D),
- wherein the first and second soluble proteins are covalently linked by a disulfide bond to form the soluble fusion protein complex.
3 more elements
Dependencies are inferred from the claim text.