Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof
AssigneeUniversity of Copenhagen
InventorsAndreas Toft Sørensen, Kenneth L. Madsen, Nikolaj Riis Christensen, Kristian Strømgaard
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Abstract
The present invention relates to virally expressed peptides with high affinity for the PDZ domains, such as the PDZ domain of PICK1. The invention furthermore relates to the therapeutic use of these peptides in prevention and/or treatment of diseases and/or disorders associated with maladaptive plasticity and/or transmission.
Claims23
-32. (canceled)
A polynucleotide comprising a sequence encoding upon expression a polypeptide comprising:
- a) a first polypeptide part comprising or consisting of an amino acid sequence capable of forming a homodimer with an identical first polypeptide part;
- and
- b) a second polypeptide part comprising or consisting of an amino acid sequence selected from the group consisting of Class I PDZ domains binding motifs (PBM), Class II PBM and Class III PBM,
- wherein the first and the second polypeptide parts are optionally operably linked via a linker.
An expression vector comprising a polynucleotide sequence encoding upon expression a polypeptide comprising:
- a) a first polypeptide part comprising or consisting of an amino acid sequence capable of forming a homodimer with an identical first polypeptide part;
- and
- b) a second polypeptide part comprising or consisting of an amino acid sequence selected from the group consisting of Class I PDZ domains binding motifs (PBM), Class II PBM and Class III PBM,
- wherein the first and the second polypeptide parts are operably linked via a linker.
A polypeptide comprising:
- a) a first polypeptide part comprising or consisting of an amino acid sequence capable of forming a homodimer with an identical first polypeptide part;
- and
- b) a second polypeptide part comprising or consisting of an amino acid sequence selected from the group consisting of Class I PDZ domains binding motifs (PBM), Class II PBM and Class III PBM,
- wherein the first and the second polypeptides are optionally operably linked via a linker.
A method for treatment or prevention of a disease and/or disorder associated with maladaptive plasticity and/or transmission comprising administration of a polynucleotide encoding a polypeptide comprising:
- a) a first polypeptide part comprising or consisting of an amino acid sequence capable of forming a homodimer with an identical first polypeptide part;
- and
- b) a second polypeptide part comprising or consisting of an amino acid sequence selected from the group consisting of Class I PDZ domains binding motifs (PBM), Class II PBM and Class III PBM,
- wherein the first and the second polypeptides are optionally operably linked via a linker, to an individual in need thereof.
Dependencies are inferred from the claim text.