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US 2022/0033449 A1Published application
Identification of channelrhodopsin-2 (chr2) mutations and methods of use
AssigneeWayne State University
InventorZhuo-Hua PAN
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Abstract
The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant ChR2 protein. Methods of the invention include administering a composition comprising a mutant ChR2 to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
Claims23
-50. (canceled)
An expression vector comprising a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 26 in which the amino acid at position 132 of SEQ ID NO:
- 26 is cysteine (C) or alanine (A), and the amino acid at position 159 of SEQ ID NO:
- 26 is cysteine (C), serine (S), or alanine (A).
Dependencies are inferred from the claim text.