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US 2022/0033444 A1Published application
Cyclic Peptides, Methods of Synthesis, and Methods of Treatment
AssigneeThe Regents of the University of California
InventorsAdam G. Kreutzer, James S. Nowick
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Abstract
Cyclic peptide compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of coronavirus. Therapeutics are also provided containing a therapeutically effective dose of one or more cyclic peptide compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or pulmonary administration.
Claims27
A cyclic peptide comprising:
- three or more amino acids, wherein a first amino acid of the cyclic peptide is a linker, wherein the linker comprises a first amide group and a first carbonyl group, wherein the first amide group is in an amide bond with a second carbonyl group a second amino acid of the cyclic peptide and the first carbonyl group is in an amide bond with a second amide group with a third amino acid of the cyclic peptide, and wherein the first amide group is 5, 6, 7 or 8 atoms apart from the first carbonyl group.
A compound of formula
- wherein:
- Xaa1 is a hydrophobic amino acid;
- Xaa2 is an amino acid capable of hydrogen bonding;
- Xaa3 is any amino acid;
- Xaa4 is any amino acid;
- and
- Laa is a linker amino acid, wherein the linker amino acid is [3-(2-aminoethyl)phenyl]-acetic acid, [4-(2-aminoethyl)phenyl]-acetic acid, 2-(5-(2-aminoethyl)furan-2-yl)acetic acid, 2-(5-(2-aminoethyl)thiophen-2-yl)acetic acid, 2-(5-(2-aminoethyl)-1H-pyrrol-2-yl)acetic acid, 6-aminohexanoic acid, 7-aminoheptanoic acid, 8-aminooctanoic acid, or 9-aminononanoic acid.
4 more elements
A method of treatment for coronavirus, comprising:
- administering to a subject an effective amount of a compound of formula
- Xaa1 is a hydrophobic amino acid;
- Xaa2 is an amino acid capable of hydrogen bonding;
- Xaa3 is any amino acid;
- Xaa4 is any amino acid;
- and
- Laa is a linker amino acid, wherein the linker amino acid is [3-(2-aminoethyl)phenyl]-acetic acid, [4-(2-aminoethyl)phenyl]-acetic acid, 2-(5-(2-aminoethyl)furan-2-yl)acetic acid, 2-(5-(2-aminoethyl)thiophen-2-yl)acetic acid, 2-(5-(2-aminoethyl)-1H-pyrrol-2-yl)acetic acid, 6-aminohexanoic acid, 7-aminoheptanoic acid, 8-aminooctanoic acid, or 9-aminononanoic acid.
4 more elements
Dependencies are inferred from the claim text.