Peptide targeting mycobacterium tuberculosis toxin-antitoxin system and use thereof
AssigneeSeoul National University R&Db Foundation
InventorsBong-Jin Lee, Sung-Min Kang, Do-Hee Kim
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Abstract
The present invention relates to a peptide targeting a toxin-antitoxin system of Mycobacterium tuberculosis and a use thereof. Specifically, the antibiotic peptide of the present invention inhibits the formation of a toxin-antitoxin complex of Mycobacterium tuberculosis without affecting an active site of the toxin, thereby inducing the death of Mycobacterium tuberculosis by means of a separated toxin. Therefore, the antibiotic peptide can be usefully used as an antibiotic composition against Mycobacterium tuberculosis.
Claims12
An antibiotic peptide that inhibits the binding of an antitoxin to one or more α3 residues or α4 residues of a Mycobacterium tuberculosis toxin protein.
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Dependencies are inferred from the claim text.